Pistachio trees have different diseases. Some of these diseases are more common and some less well known. In the current study, the successful application of knowledge and experience of farmers for control of pistachio die-back disorder was investigated. The data used is related to 286 pistachio orchards in Anar and Rafsanjan districts that were collected over a 9 year period (2010 to 2018) and in three cross times, years of 2012, 2015 and 2018. To evaluate the effect of different management factors on reducing or increasing the severity of orchard disorder and its effects on the quantity and quality of pistachio crop yield and profit, the methods of correlation coefficient, mean comparison and regression was used. Results showed that the total damage caused by this disorder is 237 million Rials per hectare per year and a 5% increase in closed shell pistachio. Also, 97% of the studied farmers knew pistachio die-back disorder but did not identify the causes. Factors such as high plant density, severe deficit irrigation, deficiency of potassium and manganese nutrients, severe alternate bearing and repeated application of volck oil to meet cold requirements exacerbate the die-back disorder. In contrast, the application of poultry, the use of phosphate and sulopotas fertilizers, and micro nutrients reduce the risk of die-back disorder. Investigating the role of farmers' abilities in controlling pistachio die-back disorder showed that knowledge and understanding of this disorder is not enough. Rather, the other three tools required are good soil and water conditions, knowledge, desire and ability to feed the pistachio orchards and the belief in sustainable orchard management and the long-term goal of maintaining the trees and crop production.